I love the idea of covering a quilt with this funky design, but marking every square didn't seem very fun. By quilting from the back with patterned backing fabric, I think this would be the easiest way to quilt the design.
This design is quilted from the edges of your quilting space into the center. So if you were quilting
a block, you would begin in the ditch around the edges of the block and quilt to the center to fill it with Twisted Square. If you're filling an extra large block make sure to baste the area securely so it doesn't shift as you quilt from the edges to the inside.
You can also quilt this design from the center to the outer edges. I need to play with this more, but I think it will work to quilt squares radiating out from the center. I do think it will be easier to quilt if all the squares
are marked so you can visualize the angle of each square in the design.